A study on diagnostic performance of different immunohematological diagnostic tests in assessing the prevalence of ABO Hemolytic Disease of Newborn in the antenatal O group mothers and their neonatal outcome in a tertiary care hospital in Northern India

Joyisa Deb,Ashish Jain,Daljit Kaur, Anupama Bahadur,Sriparna Basu,Gita Negi

Transfusion and Apheresis Science（2023）

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Abstract

•Mothers with IgG ABO antibody titer≥256 correlate with development of ABO HDN.•DAT positivity is a good predictor of ABO-HDN, especially using sensitive techniques like CAT.•Maternal IgG ABO antibody titration has the highest sensitivity & DAT has the highest specificity in prediction of ABO-HDN.

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Key words

Hemolytic Disease of Newborn (HDN),Conventional Tube Technique (CTT),Dithiothreitol (DTT),Direct Antiglobulin Test (DAT),Positive Predictive Value (PPV),Negative Predictive Value (NPV)

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