FeCl₃-Catalyzed Synthesis of Symmetrical Pyridines from Ketoxime Acetates Using DMFDMA as an Effective C1 Synthon

An efficient and facile strategy has been developed for the synthesis of symmetrical pyridines in good to excellent yields from ketoxime acetates and DMFDMA in the presence of FeCl3 at 120 °C for 6 h under argon atmosphere. In this protocol, DMFDMA acts as an effective C1 synthon. The use of inexpensive catalysts, no need for additional ligands and additives, and excellent functional group tolerance are the perks of this protocol.