Dynamics of immunological parameters in patients with multiple sclerosis after transplantation of allogeneic mesenchymal stem cells

Mesenchymal stromal stem cells (MSSCs) are a unique object for the development of new methods for the treatment of multiple sclerosis (MS) due to their immunomodulatory properties, stimulation of repair and transdifferentiation processes under certain conditions in the direction of glial cells and even neurons. The article presents the results of a study aimed at assessing the effect of allogeneic MSSC transplantation on some immunological parameters of patients with MS. The most significant changes in the immunological status were observed by 6 months of the post-transplantation period. After therapy with allogeneic MSSCs, there was no pronounced inhibition of the functional state of T-lymphocytes in response to nonspecific stimulation, which indicates the functional viability of immune system cells in maintaining antigenic homeostasis.