Saccharin‐catalyzed multicomponent cascade reactions for the synthesis of 1,2,3,4,6‐pentasubstituted piperidines
Journal of Heterocyclic Chemistry(2023)
Abstract
Abstract A convenient and efficient method is developed for the synthesis of 1,2,3,4,6‐pentasubstituted piperidines via a three‐component, one‐pot domino reaction of β‐ketoesters, aromatic aldehydes, and aromatic amines in the presence of a catalytic amount of saccharin in methanol at 40°C. The desired piperidines could be easily collected through simple filtration with excellent diastereoselectivities.
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Key words
multicomponent cascade reactions,synthesis
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