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Difficult-to-treat Diabetes Insipidus in a Patient with Midline Defect: A Case Report

Atena Seifi, Arefeh Zahmatkesh,Mahnaz Jamee, Mahbubeh Mirzaee,Masoumeh Mohkam

Authorea (Authorea)（2023）

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Abstract
Holoprosencephaly (HPE) is a complex brain malformation resulting from incomplete cleavage of the prosencephalon, occurring between the 18th and 28th day of gestation. Endocrinologic dysfunctions such as diabetes insipidus (DI), hypothyroidism, and growth hormone deficiency are common in HPE and correlated with the degree of hypothalamic non-separation.
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Key words
diabetes insipidus,midline defect,difficult-to-treat
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