Abstract IA042: Global disparities: A global approach to understanding the generative mechanisms underpinning cancer health disparities

Abstract Advances in cancer research have resulted in a decline in overall cancer incidence and deaths, and an increase in the number of cancer survivors globally. However, this progress has not been shared equally in the global community with certain populations continuing to experience significant or worsening cancer disparities. There are gaps in our understanding of the etiologies and drivers of global cancer disparities. Studying cancer health disparities systematically with a coordinated global effort offers opportunities to understand and develop context-specific interventions which may be adapted and translated across multiple global settings. The science of health disparities has advanced significantly in the past decade, resulting in a strong foundational knowledge of the causes of disparities in specific communities. Future disparities research must now recognize the inherent complex and dynamic connections and interrelationships among multiple factors from which these cancer disparities emerge. Broader use of methodological approaches that more fully account for the complex socio-cultural context in which disparities occur will enable the development of sustainable, resource- and culturally-appropriate interventions to reduce disparities in multiple global settings. To prevent, reduce, and ultimately eliminate global cancer health disparities and achieve cancer health-equity globally, a value-driven, globo-centric effort is needed to unravel the complex generative mechanisms that underpin disparities in similar socio-biological contexts across Multiple settings globally. This session aims to discuss example approaches to systematically study and address cancer health disparities globally. Citation Format: James R. Alaro, Neal A. Palafox, Lynette Ann Denny. Global disparities: A global approach to understanding the generative mechanisms underpinning cancer health disparities [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA042.