OGBN P18 Surgical Intervention in Patient with Oesophageal Absent Contractility

Abstract Background Absent contractility (AC) is a major motility disorder with poor prognosis. Surgical management for associated comorbidities of AC are often challenging such as in GORD patients where antireflux surgery may be contraindicated or undiagnosed achalasia manifesting with normotensive integrated relaxation pressure would be deprived of surgical myotomy. Thus, it’s crucial to explore potential surgical interventions for patients with AC from both ends of the spectrum. This study will investigate the two extremes of AC and seek to determine suitable strategies for patient selection and offer insights into the management of AC through surgical intervention. Methods This is a retrospective study of patients undergone high-resolution manometry (HRM) between January 2022 to June 2023 and were diagnosed with AC based on ten 5ml water swallows. Patients were followed-up with provocative multiple water swallowing (MWS) and solid bolus swallow (SBS) assessments. Peristalsis invoked by MWS with Distal Contractile Integral (DCI) >100mmHgscm or SBS with DCI >405mmHgscm are adequate peristaltic vigour for consideration of floppy Nissen fundoplication. Patients with absolute AC on provocative stimulation and without peristaltic remnants during the HRM recording underwent oesophageal transit testing in consideration for Heller’s myotomy. Results Total of 115 patients were included (female:male=59:56, mean age 56 years old) with 43 patients (37.4%) demonstrating peristalsis on adjunctive testing (SBS assessment provoking peristalsis was greater by 3.2 folds to MWS [p=0.0004]). In 72 patients with failed adjunctive testing, 6 patients (8.3%) invoked peristalsis (DCI>100mmHgscm) from dry swallows (largest DCI observed: 1000) and 29 patients (40.2%) demonstrated peristaltic remnants (DCI<100mmHgscm). 37 patients (32.2%) had absolute AC with 21/37 patients (56.7%) were diagnosed with achalasia on transit testing (7 patients are still pending tests). AC in 9 patients originate from aetiologies where surgery would not benefit the patients. Conclusions Approximately 37.4% of patients with AC were suitable for floppy Nissen fundoplication, while 32.2% required Heller's myotomy. Surgical intervention was postponed if peristaltic remnants was observed and pending complete diminishment or recovery with prokinetic therapy. Overall, surgical intervention may be considered in nearly 70% of patients with AC.