An inducible mouse model of heart failure targeted to cardiac Drd5 deficiency detonating mitochondrial oxidative stress

Guoqing Li,Xing Liu, Anxiong Long, Jianghao Feng, Shiyun Sun,Zhiwei Yang, Rongyan Jiang,Xiaoliang Jiang

INTERNATIONAL JOURNAL OF CARDIOLOGY（2024）

引用 0|浏览10

暂无评分

摘要

•Cardiac Drd5 leads to hypertrophic cardiomyopathy and heart failure through ROS, NADPH oxidase, and mitochondrial dysfunction.•Drd5 myh6fl/fl-creERT2 mice mirror human heart failure, filling a gap in oxidative stress-induced HF models.•Targeting Drd5-related pathways offers potential therapeutic avenues for heart failure treatment.

查看译文

关键词

Heart failure,Experimental animal model,Dopamine D5 receptor (D5R),Reactive oxygen species (ROS)

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要