Difference and connection of clinical features and ANA patterns in new-onset SLE cross age groups

Muxue Gong, Ning Li, Cheng Sun, Daesik Hong, Xin Wang,Ming Ye,Tao Wang,Zhijun Li,Changhao Xie

Research Square (Research Square)(2023)

引用 0|浏览2
暂无评分
摘要
Abstract Background Systemic lupus erythematosus (SLE) is a common autoimmune disease, the clinical features of which will change a lot by onset age. To investigate the differences in autoantibodies, clinical features, and the relationship between antinuclear antibody (ANA) patterns, autoantibodies, and symptoms among different age groups. Methods We conducted a retrospective cohort study involving 556 patients diagnosed with SLE. These patients were classified into three groups: Group 1 comprised individuals with juvenile-onset SLE (< 18 years); Group 2 included those with early-onset adult SLE (18–50 years); and Group 3 consisted of patients with late-onset SLE (≥ 50 years). We utilized a clustering heatmap to identify variations and associations of autoantibodies among the three groups. The Kruskal-Wallis test was performed to compare autoantibodies, clinical manifestations, and laboratory measurements across the groups. The Chi-square test and correlation heatmap were used to analyze the relationship of ANA patterns with autoantibodies and symptoms. Results Our findings revealed that patients with late-onset SLE had a significantly lower prevalence of anti-dsDNA (56.0% vs. 70.5%, P = 0.016) and anti-Sm (46.8% vs. 60.6%, P = 0.036) compared to those with early-onset adult SLE. At the time of initial diagnosis, the presence of anti-R52 antibody in patients with juvenile-onset SLE was higher than in those with early-onset adult SLE (25.7% vs. 54.6%, P = 0.004). Malar rash was more common as an initial symptom in patients with juvenile-onset SLE, while interstitial lung disease was more prevalent in those with late-onset SLE. Conclusions Late-onset SLE patients exhibited more severe kidney damage and a higher likelihood of infection. Early-onset adult SLE patients had a higher likelihood of elevated disease activity. Late-onset patients with a speckled ANA pattern were more prone to developing Raynaud's phenomenon. It is important for early-onset adult SLE patients with a homogeneous ANA pattern to be vigilant about the possibility of renal disorders and skin involvement. These novel findings contribute to the diagnosis and prevention of SLE.
更多
查看译文
关键词
clinical features,sle,ana patterns,age,new-onset
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要