Mechanism of circDYM/CEBPB/ZC3H4 axis in LPS-induced Microglial Apoptosis

Abstract Circular RNAs (circRNAs) are a subtype of non-coding RNAs and contribute to the various central nervous system (CNS) diseases. However, microglia apoptosis which is regulated by circRNAs in major depressive disorder (MDD) is incompletely clear. Herein, we have shown that the circular RNA DYM (circDYM) binds to the transcription factor CEBPB, thereby releasing repression of CEBPB target gene ZC3H4 transcription. The result of our study provides new insights in function of circDYM to microglia apoptosis in depression. Taken together, we identify that circRNA drives neuroinflammation and serves as a new potential target for therapy of depression.