Correlation between virological indexes and immune inflammation-related factor levels in acute HIV-1-infected patients

Purpose: This study aimed to compare the different expression levels of 12 immune inflammation-related factor in plasma of untreated acute HIV-1-infected patients with different HIV-1 RNA or HIV-1 DNA levels.Methods: 70 acute HIV-1-infected patients without any anti-retrovirus therapy (ART) were selected.The levels of patients' HIV-1 RNA, HIV-1 DNA and 12 different immune inflammation-related factors in plasma were detected and compared. Results:The expression levels of CXCL10, CXCL11, CXCL13, IL-6, IL-16 and IL-18 were different between the different HIV-1 RNA level groups and the different HIV-1 DNA level groups.There was no significant difference in the expression levels of the chemokines IL-8, CCL2, CCL20 and CCL22 between the groups.The stratified analysis using 200 cells/μL as the CD4+ T cell count cut-off value showed similar intergroup differences.