Renal Response Outcomes of the EuroLupus and NIH Cyclophosphamide Dosing Regimens in Childhood‐Onset Proliferative Lupus Nephritis
Arthritis & Rheumatology(2023)
摘要
Objective We compared clinical characteristics and renal response in patients with childhood‐onset proliferative lupus nephritis (LN) treated with the EuroLupus versus NIH cyclophosphamide (CYC) regimen. Methods A retrospective cohort study was conducted at 11 pediatric centers in North America that reported using both CYC regimens. Data were extracted from the electronic medical record at baseline, 3, 6 and 12 months after treatment initiation with CYC. To evaluate the adjusted association between CYC regimen (EuroLupus vs. NIH) and renal response over time, generalized estimating equations with a logit link were used. An interaction between time and CYC regimen was included, and a contrast between CYC regimens at 12‐months was used to evaluate the primary outcome. Results One hundred and forty‐five patients (58 EuroLupus, 87 NIH) were included. EuroLupus patients were on average older at the start of current cyclophosphamide therapy, had longer disease duration, and more commonly had relapsed or refractory LN compared to the NIH group. After multivariable adjustment, there was no significant association between CYC regimen and achieving complete renal response at 12 months (Odds Ratio (OR) of response for the EuroLupus regimen, reference NIH regimen: 0.76, 95% Confidence Interval (CI) 0.29, 1.98). There was also no significant association between CYC regimen and achieving at least a partial renal response at 12 months (OR 1.35, 95% CI 0.57, 3.19). Conclusion Our study failed to demonstrate a benefit of the NIH regimen over the EuroLupus CYC regimen in childhood‐onset proliferative LN. However, future prospective outcome studies are needed. image
更多查看译文
关键词
proliferative <scp>eurolupus</scp> nephritis,cyclophosphamide dosing regimens,renal
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要