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Total synthesis of applanatumol A

Kyohei Uchida,Yuichiro Kawamoto,Toyoharu Kobayashi,Hisanaka Ito

Chemical Communications（2023）

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Abstract
The first total synthesis of applanatumol A has been achieved in a highly stereocontrolled manner. The synthetic method includes Fráter-Seebach alkylation, intramolecular aldol reaction, and stereoselective tandem cyclization.
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total synthesis
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