Missense Variant in Ceramide Synthase 2 (CERS2) is Associated with Higher Overnight Energy Expenditure and Hepatic Insulin Resistance in Healthy Humans

Sascha Heinitz,Michael Traurig,Jonathan Krakoff, Philipp Rabe,Claudia Stäubert,Michael Stümvoll,Matthias Blüher,Leslie J. Baier,Paolo Piaggi

Diabetologie Und Stoffwechsel（2023）

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摘要

Research aim Genetic determinants of inter-individual differences in energy expenditure (EE) remain largely unknown. Participating in cellular signaling pathways, ceramides were identified as putative EE regulators. Current study investigated whether genetic variants within enzymes involved in ceramide synthesis and degradation affect EE.

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关键词

hepatic insulin resistance,ceramide synthase,insulin resistance,cers2

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