Risk Factors Related to Venous Thromboembolism at Three-months Following Joint Replacement in Chinese Population

Abstract Background: This study reports the risk factors related to venous thromboembolism (VTE) at 3-months following joint replacement in Chinese population. Methods: We conducted a retrospective study enrolled the patients who received joint replacement from February 2015 to December 2018. VTE at 3-months was investigated against a total of 16 factors, including age, gender, Body Mass Index, season of surgery been performed, pre-surgical clotting function, type of surgery, selection of mini-invasive approach, VTE of lower limbs one-day before and after surgery, and previous history of diseases including thrombotic disease, smoking, tumor, diabetes, hypertension, cardiac disease, anticoagulants usage. Results: A total of 1782 patients were enrolled. Gross incidence of VTE at 3-months following joint replacement surgery was 10.5%. In the 1744 patients included for the final analysis, the VTE at one-day after surgery (OR = 7.633), surgery in autumn (OR = 1.874), increased age per year (OR = 1.023), female gender (OR = 1.828), previous thrombotic disease (OR = 1.592) were related to the VTE at 3-months after surgery. Conclusion: Higher age, female gender, previous thrombotic disease, VTE immediate after surgery and surgery in autumn were risk factors related to higher incidence of VTE at 3-months following joint replacement surgery. More aggressive prophylaxis and frequent follow-up is advised to patients identified with these risk factors.