Bioinformatics Tools to Discover and Validate Cancer Biomarkers

Cancer is the most deadly disease that causes death. Most likely, cancer is a problem in developed nations, with liver cancer coming in third in terms of mortality rates globally. Other than breast cancer, which is ranked fourth in the world, ovarian cancerOvarian Cancer is the most dangerous cancer in terms of maternal cancer. Ovarian cancerOvarian Cancer which is epithelial ovarian cancerEpithelial Ovarian cancer (EOC) accounts for 90% of cases. Hox genesHomeobox (Hox) genes are typically expressed during organogenesis, but HOXA9 and HOXA11 are responsible for and involved in the molecular pathway of ovarian cancerOvarian Cancer. Ovarian cancerOvarian Cancer has many genes involved in the molecular pathway, and it can validate ovarian cancerOvarian Cancer treatment and therapies. In this current study, we examined bioinformatics resources for ovarian cancerOvarian Cancer biomarker validation for ovarian cancerOvarian Cancer therapies. In ovarian cancerOvarian Cancer, the genes CREB1, CD38, SIRTs, TP53, WT1Wilms tumour gene (WT1), many miRNAs, etc., play novel biomarker roles and can be validated for ovarian cancerOvarian Cancer treatment. Many ovarian cancerOvarian Cancer biomarkers are reviewed and validated through bioinformatics tools. Different genes were discovered and validated using GEO and common DEGsDifferentially expressed genes (DEGs) through cBioPortalCBio Cancer Genomics Portal (cBioPortal), KEGGKEGG, functional enrichment analysis, PPI, and oncomineONCOMINE along with immunohistology. Many hub genes were found and reviewed using common DEGsDifferentially expressed genes (DEGs) and GEO.