Association of Euterpe oleracea, Bixa orellana, Myciaria dubia, and Astrocaryum aculeatum (the Terasen® Nutraceutical) Increases the Lifespan of Caenorhabditis elegans

Ester Lopes de Melo, Beatriz Tavares, Nayara Nílcia Dias Colares,Aline Lopes do Nascimento,Helison de Oliveira Carvalho, Andrés Navarrete Castro, Arlindo César Matias Pereira, Carlos Eduardo Winter, Iracirema da Silva Sena, Luiz Fernando Moreira, José Carlos Tavares Carvalho

Journal of ageing and longevity(2023)

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Abstract
Aging is a complex process associated with tissue degeneration and an increased risk of age-related diseases. This study aimed to evaluate the impact of Terasen®, a nutraceutical containing standardized extracts of Euterpe oleracea, Myrciaria dubia, and purified oil of Bixa orellana and Astrocaryum aculeatum on the lifespan of Caenorhabditis elegans. The findings demonstrated that Terasen® exhibited significant radical scavenging in vitro, decreased the feeding behavior of C. elegans without affecting the animals’ final size, increased the eggs laid in a concentration-dependent fashion, although the total progeny was reduced compared to the control, and increased the median and maximum lifespan. These findings suggest that Terasen® may improve the lifespan in C. elegans, warranting further investigation.
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Key words
longevity,healthspan,lifespan,nutraceuticals
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