Glycolysis and acute lung injury: A review

Yang Yi, Jun Chen, Nan Li, Yue Huang,Jichao Peng,Xiaoran Liu

Asian Pacific Journal of Tropical Medicine(2023)

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摘要
Acute lung injury is featured as diffuse pulmonary edema and persistent hypoxemia caused by lung or systemic injury. It is believed that these pathological changes are associated with damage to the alveolar epithelium and vascular endothelium, recruitment of inflammatory cells, and inflammatory factor storms. In recent years, the metabolic reprogramming of lung parenchymal cells and immune cells, particularly alterations in glycolysis, has been found to occur in acute lung injury. Inhibition of glycolysis can reduce the severity of acute lung injury. Thus, this review focuses on the interconnection between acute lung injury and glycolysis and the mechanisms of interaction, which may bring hope for the treatment of acute lung injury.
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关键词
Acute lung injury,Glycolysis,Hypoxia-inducible factor 1,Endothelium,Macrophages
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