Mechanistic insights into NH4OAc-promoted imine dance in Rh-catalysed multicomponent double C−H annulations through N-retention/-exchange dual channel

The methodology and mechanism of Rh( iii )-catalyzed multicomponent double C–H annulations to assemble axial 1,1′-biisoquinolines and C-bridged 1,1′-bisisoquinolines with controllable 14 N/ 15 N editing in one shot have been developed.