Axillary vein puncture versus cephalic vein cutdown for cardiac implantable electronic device implantation: A meta‐analysis

Abstract Introduction Cephalic vein cutdown (CVC) and axillary vein puncture (AVP) are both recommended for transvenous implantation of leads for cardiac implantable electronic devices (CIEDs). Nonetheless, it is still debated which of the two techniques has a better safety and efficacy profile. Methods We systematically searched Medline, Embase, and Cochrane electronic databases up to September 5, 2022, for studies that evaluated the efficacy and safety of AVP and CVC reporting at least one clinical outcome of interest. The primary endpoints were acute procedural success and overall complications. The effect size was estimated using a random‐effect model as risk ratio (RR) and relative 95% confidence interval (CI). Results Overall, seven studies were included, which enrolled 1771 and 3067 transvenous leads (65.6% [ n = 1162] males, average age 73.4 ± 14.3 years). Compared to CVC, AVP showed a significant increase in the primary endpoint (95.7 % vs. 76.1 %; RR: 1.24; 95% CI: 1.09–1.40; p = .001) (Figure 1). Total procedural time (mean difference [MD]: −8.25 min; 95% CI: −10.23 to −6.27; p < .0001; I 2 = 0%) and venous access time (MD: −6.24 min; 95% CI: −7.01 to −5.47; p < .0001; I 2 = 0%) were significantly shorter with AVP compared to CVC. No differences were found between AVP and CVC for incidence overall complications (RR: 0.56; 95% CI: 0.28–1.10; p = .09), pneumothorax (RR: 0.72; 95% CI: 0.13−4.0; p = .71), lead failure (RR: 0.58; 95% CI: 0.23–1.48; p = .26), pocket hematoma/bleeding (RR: 0.58; 95% CI: 0.15–2.23; p = .43), device infection (RR: 0.95; 95% CI: 0.14–6.60; p = .96) and fluoroscopy time (MD: −0.24 min; 95% CI: −0.75 to 0.28; p = .36). Conclusion Our meta‐analysis suggests that AVP may improve procedural success and reduce total procedural time and venous access time compared to CVC.