Tf₂O‐Catalyzed Tandem Cyclization/Trifluoromethylselenolation of Alkynes for Synthesis of CF₃Se‐Containing Heterocycles

Abstract Herein, the tandem synthesis of various CF 3 Se‐containing heterocyclic compounds has been developed, using Tf 2 O as the catalyst and trifluoromethyl selenoxides as the electrophilic trifluoromethylselenolation reagents. This process is characterized by its mild conditions, ease of operation, and good functional group compatibility. A variety of alkynes could be transferred into CF 3 Se‐containing indoles, benzofurans, benzothiophenes, isoquinolines and chromenes in good yields. A key step involving the formation of the electrophilic CF 3 Se species was proposed.