Efomycine U, a new C₂-asymmetric elaiophylin derivative from Streptomyces malaysiensis DSM 4137

AbstractAbstractChemical examination of an actinomycete strain Streptomyces malaysiensis DSM 4137 derived from a soil sample derived isolate Streptomyces sp. DSM 3816, yielded a new C2-asymmetric elaiophylin derivative efomycine U (1) and a known analogue halichoblelide D (2). These structures were unambiguously elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. All compounds isolated were subjected to antimicrobial, cytotoxic and immnosuppressive activities evaluation.Graphical AbstractKeywords: Streptomyces malaysiensisefomycine Ustructure identificationbiological activities Disclosure statementThere are no competing or conflicts of interest to declare.Additional informationFundingThis work was co-financed by grants of the National Natural Science Foundation of China (No. 82160675/81973229), the Key Science and Technology Project of Hainan Province (ZDKJ202018), the Key Research Program of Hainan Province (ZDYF2021SHFZ108), Collaborative Innovation Center Foundation of Hainan University (XTCX2022STB01) and Guangdong Key Laboratory of Marine Materia Medica Open Fund (LMM2021-4) are gratefully acknowledged. Prof. Dr. Jing Xu gratefully acknowledges Prof. Peter F. Leadlay from University of Cambridge for providing S. malaysiensis DSM 4137 strain in this research and Chinese Scholarship Council of the Ministry of Education to support her postdoctoral training in Peter F. Leadlay’s lab.