Personal care products related phenols and parabens in relation to urinary incontinence in the US population

Abstract Our research aims to assess the association of personal care products (PCPs) related parabens(PBs) and phenols(PNs) including Triclosan(TCS), Bisphenol A(BPA), Benzophenone-3(BP-3), Butylparaben(BPB), Ethylparaben(EPB), Methylparaben(MPB) and Propylparaben(PPB) detected in urine samples with urinary incontinence in the US population. A cross-sectional analysis was conducted based on the data from the National Health and Nutrition Examination Survey (Nhanes) 2007-2016. A total of 7,690 participants diagnosed by self-reported questionnaires were included in the final analysis. Of theseparticipants, 12.80% reported SUI, 11.80% reported UUI and 10.22% reported MUI. In the fully adjusted multivariable models, BP-3 exposure showed a positive association with SUI (OR 1.07 95% CI1.02-1.14 p=0.045), BPA exposure increased the risk of UUI (OR 1.21 95% CI1.01-1.44 p=0.046) and MUI (OR 1.26 95% CI 1.02-1.54 p=0.029). Furthermore, TCS was found related to a decreased incidence of MUI (OR 0.87 95%CI 0.79-0.97 p=0.009). No significant correlation was found between parabens and urinary incontinence. Among the female population, our research revealed that BPA exposure increased the risk of MUI (OR 1.28 95% CI 1.01-1.63 p=0.043) when covariables such as vaginal deliveries, hysterectomy, and hormone use history were included. The maximal tertile of BP-3 showed a higher likelihood of SUI and MUI among participants compared with the lowest tertile. All in all, exposure to BPA, TCS, and BP-3 may engaged in the development of urine incontinence in various ways.