Saliva and urine from persons with hemophilia A trigger coagulation bypassing factor VIII

Hamostaseologie(2023)

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Abstract
Introduction We previously demonstrated that saliva and urine from healthy individuals trigger coagulation via tissue factor/activated factor VII (TF/FVIIa) complex exposing extracellular vesicles (EVs). In persons with hemophilia A, saliva and urine may provide hemostatic protection via TF/FVIIa complex exposing EVs.
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Key words
hemophilia,trigger coagulation,viii
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