Innovative Fixed Bed Bioreactor Platform: Enabling Linearly Scalable Adherent Cell Biomanufacturing with Real-Time Biomass Prediction from Nutrient Consumption

Vasiliy N. Goral,Yulong Hong, Jeffery J. Scibek, Yujian Sun,Lori E. Romeo, Abhijit Rao,Daniel Manning, Yue Zhou, Joel A. Schultes, Vinalia Tjong, Dragan Pikula, Kathleen A. Krebs,Ann M. Ferrie, Stefan Kramel,Jennifer L. Weber, Todd M. Upton,Ye Fang,Zara Melkoumian

BIOTECHNOLOGY JOURNAL（2024）

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adeno-associated virus vector,adherent cell biomanufacturing,ascent,biomass,computational fluid dynamics,fixed bed bioreactor,oxygen uptake rate

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