Study on the potential mechanism of Qingxin Lianzi Yin Decoction on renoprotection in db/db mice via network pharmacology and metabolomics

Phytomedicine(2023)

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摘要
•This study established index component content determination method of QXLZY.•This study is the first time to elucidate that amino acid metabolism was disturbed in the kidney of db/db mice, which could be callback by QXLZY.•Untargeted metabolomics studies were preformed to investigate by UHPLC-LTQ-Orbitrap MS on urine, serum, and kidney samples.•The potential therapeutic targets of QXLZY in the treatment of DN were investigated by network pharmacological analysis.•Targeted metabolomics by UHPLC-QQQ-MS/MS was performed on urine, serum, and kidney samples for validation.
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关键词
Qingxin Lianzi Yin Decoction,Diabetic nephropathy,Metabolomics,Network pharmacology
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