Endothelial Overexpression of TGF-β-Induced Protein Impairs Venous Thrombus Resolution: Possible Role in CTEPH

•Increased expression and elevated plasma levels of TGFBI were observed in endothelial cells and plasma of patients with CTEPH, and the latter significantly decreased on pulmonary endarterectomy and removal of thrombotic material from the pulmonary artery.•Lentiviral overexpression of TGFBI in human pulmonary artery endothelial cells induced gene expression changes similar to those seen in primary ECs isolated from patients and altered human blood clot resolution.•Delayed venous thrombus resolution was also observed in mice with elevated TGFBI plasma levels after induction of venous thrombosis.