Association of 8-hydroxy-2’-deoxyguanosine with motoric cognitive risk in elderly Chinese people: RUGAO longevity and aging cross-sectional study

Abstract Background: Motor cognitive risk syndrome (MCR) is a pre-dementia and disability state combining objective slow walking speed and subjective cognitive complaints (SMCs). To explore the risk factors and the association between 8-hydroxy-2’-deoxyguanosine (8-OHdG) and motor cognitive risk syndrome (MCR) in Chinese community-dwelling elderly people. Methods: A total of 1312 participants were involved in this study based on the data of the Rugao Longevity and Aging Study (RuLAS). The MCR was characterized by subjective memory complaints (SMCs) and slow walking speed. The SMCs were defined as a positive answer to the question ‘Do you feel you have more problems with memory than most?’ in a 15-item Geriatric Depression Scale. Slow walking speed was determined by one standard deviation or more below the mean value of the patient’s age and gender group. The plasma of 8-OHdG were measured by a technician in the biochemistry laboratory of the Rugao People’s Hospital during the morning of the survey. Results: The prevalence of MCR was 7.9%. After adjusting the other covariates, the elder (OR 1.057, 95% CI 1.010–1.106; p = 0.018), cerebrovascular disease history (OR 2.155, 95% CI 1.206–3.850; p = 0.010), and elevated level of 8-OHdG (OR 1.007, 95% CI 1.002–1.012; p = 0.003) showed obvious relevance to MCR. Conclusions: This study indicated These results may suggest that the elevated 8-OHdG was associated with the increased risks of MCR in elderly community.