FRI035 Comparative Study Of The Changes In Body Composition According To Age And The Associations With The Risk Of Diabetes Mellitus By Races

Abstract Disclosure: S. Jang: None. K. Kim: None. C. Kim: None. S. Park: None. Introduction: The changes in body composition with aging are known to be associated with the risk of various chronic diseases. But the body composition changes with age among different races, is not well studied. This study aimed to investigate the racial differences in the changes of body composition according to age and the association with prevalent diabetes mellitus. Methods: A total of 37,153 participants was include in the study. 27,864 Korean from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008-2011 and 9,289 from the National Health and Nutrition Examination Survey (NHANES) 2003-2006 whose age ranged from 20 to 85 years were analyzed. Body composition was measured by dual-energy X-ray absorptiometry (Hologic Horizon) in both cohorts. Relative body composition measures based on young adult (20-29 years) were compared. The association of body composition measures and diabetes were analyzed. Results: Compare to other three races from NHANES, Korean men and women had a lower BMI. Total percentage fat tended to increase with age in all races, but degree of increase with age was not higher in Korean men than in other races and a similar trend was observed in Korean women. Regarding the changes in lean mass, men and women showed different patterns. In men, non-Hispanic white showed peak levels in their 40s and then tended to decrease. All other races showed peaks in their 20s and 30s, and subsequently decreased. Compared to other races, the decline according to age was the largest in Korean men. For women, in all races, the pattern was maintained even after their 20s until their 40s or 50s, and then decreased. The degree of decline was similar in all races. In men, higher fat percentage and lower lean mass were associated with prevalent diabetes in all races. In women, however, higher fat percentage and lower lean mass were associated with prevalent diabetes in only Korean and non-Hispanic white. Conclusion: The changes in body composition according to age vary by race and its association with prevalent diabetes also differs. The clinical significance of changes in body composition according to age and race in chronic diseases needs to be further clarified. Presentation: Friday, June 16, 2023