Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells.

Luke S Cox,Marisol Alvarez-Martinez,Xuemei Wu,Leona Gabryšová,Raphaëlle Luisier,James Briscoe,Nicholas M Luscombe,Anne O'Garra

Wellcome open research（2023）

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摘要

These data show that Blimp-1 and c-Maf positively and negatively regulate a network of both unique and common anti-inflammatory and pro-inflammatory genes to reinforce a Th1 response in mice that will eradicate pathogens with minimum immunopathology.

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unique proinflammatory gene networks,c-maf

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