Impact Of Mir-106b And ATF5 3′UTR Polymorphisms On The Risk Of Hepatocellular Cancer In A Guangxi Population

Abstract Objectives: Polymorphisms of miRNAs have become a powerful tool for studying disease biology and are used in the prognosis and diagnosis of various diseases, including liver cancer. In this research, we want to evaluate the effect of miR-106b and ATF5 polymorphisms on hepatocellular cancer (HCC). Methods: Three single nucleotide polymorphisms on miR-106b and ATF5 were selected for genotyping by Agena MassARRAY in 813 HCC patients and 896 healthy controls. After analysis using PLINK software, Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression analysis to assess the risk of HCC. Results: We evaluated the combined effect of SNP rs2261360, rs1527423 and rs8647 on the risk of HCC and found that the combined 1-3 risk genotypes were significantly associated with the high risk of HCC (OR = 1.52, 95% CI = 1.09‐2.12, P = 0.013) after adjusting for variables such as sex, age, drinking history, smoking history, HBV infection. Further stratification analysis showed that Similar joint effects of these 3 SNPs restricted the risk of HCC in males, non-smoking, non-drinking, and people infected with HBV were more pronounced related to a decreased HCC risk. Conclusions: This study provides evidence that miR-106b rs2261360 decreased the risk of HCC. The miR-106b rs2261360 wild type, rs1527423 mutant, and ATF5 rs8647 wild type may collectively contribute to the risk of HCC.