In-situ gelling platform for Ocular Drug delivery system: A new Paradigm

Abstract: One of the most promising novel drug delivery systems is an in-situ gel, which uses a unique 'Sol to Gel' conversion to help with the slow and steady release of pharmaceuticals. An in-situ gel system enters the body as a solution but transforms into a gel once it encounters the body's internal environment. Traditional methods of ocular drug delivery, such as suspensions, eye drops, and ointments, have a number of drawbacks. These include lacrimation, obscured vision, and, most importantly, rapid precorneal clearance. As a result, many innovative methods have been created in order to address these shortcomings. In-situ gel, minidisc, ocusert, nanosuspension, collagen shield, nanoparticulate, system, niosomes, ocular iontophoresis, liposome, ocular film, dendrimers, and other methods are among them. Ocular medication delivery systems have come a long way recently, and one of the most recent innovations is in-situ ocular gel. The polymers (natural, semisynthetic, or synthetic) that make up the in-situ ocular gel system's delivery vehicle have the unique feature of a sol-gel transition when subjected to the effect of a biological stimulus, such as a change in temperature, pH, or ions. Physical appearance, clarity, pH, gelling ability, isotonicity evaluation, sterility, viscosity, In vitro drug release, and irritancy tests are all investigated in in-situ ocular gels.