Sdps-42 metastatic non-small cell lung cancer (nsclc) and brain edema: a topographical and clinicopathologic investigation

Tumor-associated vasogenic brain edema is a well-known contributor of morbidity and mortality in patients with metastatic disease to the brain. It is widely accepted that metastatic disease to the brain is associated with extensive edema and can cause increased symptomatology such as pain, neurologic deficit, and elevated intracranial pressure depending on extent and location. We present a retrospective artificial intelligence (AI) mediated analysis of radiological and clinicopathologic data including specific molecular markers, presenting symptoms, and tumor location of 86 patients with non-small cell carcinoma of the lung (NSCLC) and brain metastases who underwent surgical resection and were not previously on steroids. We found that overall, tumors in all locations demonstrated a mean 10:1 edema to tumor ratio (ETR) and an occipital tumor location was associated with a significantly elevated ETR. Within our cohort there were no other factors that were significantly associated with ETR. This study demonstrates a proof of concept that NSCLC is associated with significant peritumoral edema and that topographical factors may be associated with increased extent of edema.