Coimmunization with Preerythrocytic Antigens alongside Circumsporozoite Protein Can Enhance Sterile Protection against Plasmodium Sporozoite Infection

В. И. Вигдорович,Hardik Patel,Alexander Watson,Andrew Raappana,Laura M. Reynolds,William Selman,Suzannah Beeman,Paul T. Edlefsen,Stefan H. I. Kappe,D. Noah Sather

Microbiology spectrum（2023）

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摘要

The currently approved malaria vaccine targets a single parasite protein (CSP) and results in only partial protection. We tested several additional vaccine targets in combination with CSP to identify those that could enhance protection from infection upon challenge in the mouse malaria model.

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关键词

circumsporozoite protein,circumsporozoite infection,preerythrocytic antigens,coimmunization,sterile protection

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