Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway

Hayato Urushima,Tsutomu Matsubara,Masaaki Miyakoshi,Shioko Kimura,Hideto Yuasa,Katsutoshi Yoshizato,Kazuo Ikeda

American Journal of Physiology-gastrointestinal and Liver Physiology（2023）

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摘要

Our study first revealed that hypo-osmolarity-induced mechanotransduction enhanced calcium-mediated AKT signaling via TRPV2 activation, resulting in contributing to apoptosis resistance. The finding indicates a possible view that liver cirrhosis-induced hyponatremia promotes hepatocellular carcinogenesis.

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关键词

apoptosis resistance,hypo-osmolarity,akt-bcl

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