ZnT8 loss-of-function accelerates functional maturation of hESC-derived beta cells and resists metabolic stress in diabetes

Qin Ma,Yang Xiao, Wenjian Xu,Mei Wang, Li S, Zhibo Yang,Min Xu, T Zhang, Zhang Zn, Hu R, Q. Su, Fan Yuan, Ting Xiao, Xiuli Wang, Qian He,Jie Zhao, Chen Zj, Sheng Zhou, Meng Chai, Haibin Wang,Shi Wei, Qingqing Deng, Xiaoguang Cheng,Wei Li

Yearbook of pediatric endocrinology（2023）

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Abstract

Brief summary: In this experimental study, genome editing and in vitro pancreatic differentiation of human pluripotent stem cells (SC) were used to generate ZNT8 loss-of-function (LOF) SC-β-cells. These cells showed accelerated functional maturation, increased insulin secretion and improved resistance to metabolic stress. Transplantation of ZnT8 LOF SC-β-cells into mice with preexisting diabetes significantly improved their glucose levels.

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Key words

diabetes,metabolic stress,beta cells,loss-of-function,hesc-derived

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