Timely surgical treatment of fallopian tubal pregnancy and interstitial pregnancy have no differential effect on intrauterine pregnancies after in vitro fertilization-embryo transfer

Abstract Background Due to the specific nature of interstitial pregnancy (IP), there are significant risks to both the mother and the foetus in women with a heterotopic interstitial pregnancy. IP alone has been analysed as a site-specific ectopic preganncy in previous studies, however, according to the latest European Society of Human Reproduction and Embryology criteria, IP is classified as tubal pregnancy. If IP can be classified as tubal pregnancy, it means that there is no difference in the effects of these two on IUPs. Under the premise of timely surgery, disposing of IPs and tubal pregnancy (excluding IPs) should also have no differential effect on IUPs. Methods HP-tube and HIP patients seen at our hospital from January 2005 to December 2020 were included. All included patients were diagnosed by transvaginal sonography (TVS), and EPs were confirmed by surgery and pathological analysis. The IUP outcomes after surgical treatment of the EPs were compared between the HP-tube group (n = 464) and the HIP group (n = 206). Results Regarding IUPs, there was no significant difference between the HP-tube group and the HIP group in postoperative miscarriage (6.9% vs. 6.8%, odds ratio (OR) = 1.859, 95% confidence interval (CI) (0.807–4.279)), early spontaneous miscarriage (19.61% vs. 18. 93%, OR = 0.788, 95% CI (0.495–1.255), p = 0.316), and late miscarriage rates (0.43% vs. 0.49%, OR = 0.823, 95% CI (0.070–9.661), p = 0.877). There was no significant difference between the two groups in preterm birth (7.33% vs. 6.80%, OR = 1.044, 95% CI (0.509–2.139), p = 0.907), live birth (73.92% vs. 74.27%, OR = 1.010, 95% CI (0.665–1.534), p = 0.964), or perinatal mortality rates (1.51% vs. 0.49%, OR = 1.949, 95% CI (0.225–16.904), p = 0.545). Conclusions After early diagnosis and treatment of EPs, heterotopic fallopian tubal pregnancy and heterotopic interstitial pregnancy could achieve comparatively similar outcomes.