D Vitamini Eksikliğine Bağlı Sekonder Hiperparatiroidizm’in Kemik Üzerine Etkisinin Sağlıklı Kontrol Grubu ile Karşılaştırılması

Aim: In healthy individuals, to demonstrate that adequate vitamin D status protects against osteoporosis by improving bone mineral density and reducing the risk of fractures. Material and method: Fifty patients with high parathyroid hormone secondary to low vitamin D level and 50 patients with normal parathyroid hormones were included in the study as the control group. Results: Of the 50 patients with secondary hyperparathyroidism due to vitamin D deficiency included in the study, 45 (90%) were female and 5 (10%) were male. In the control group with normal parathyroid hormone, 44 (88%) were female and 6% (12%) were male. The median age in the hyperparathyroid group was 70.5 (66-73) and in the parathyroid hormone normal group it was 71 (69-73). This median mean age was significant (p 0.004). In the group with secondary hyperparathyroidism; The median PTH value was 99.5 (66-205.9) and 49.8 (27-61.5) in the control group, with a significant difference (p < 0.001). While 25-Hydroxy Vitamin D level was 10.73 (4.64-34.1) in the group with normal parathyroid hormone level, it was 18.63 (6.21-65.1). This created a significant difference in both groups (p < 0.001). According to the results of bone densitometry in the hyperparathyroidic and control groups. no significant difference was found between bone mineral density (BMD). 0.92 (0.66 – 1134), 0.93 (0.75 – 1293), (p0.095). However, for the femur, the results in T and Z scores were significant (p 0.027- p 0.027), whereas for the supine (spine), no significant difference was observed between the T and Z scores (p 0.358- p 0.265). Conclusion: . Especially when the vitamin D level falls below 10 ng/mL, PTH begins to respond. Beyond these observations, a normal serum 25(OH)D concentration is particularly important in preventing femur fractures, but its significance for vertebral fractures is unclear.