Increased N6-methyladenosine is related to the promotion of the methyltransferase METTL14 in ovarian aging

The ovary is a vital female reproductive organ that func-tions to produce oocyte gametes and cyclically expressed sex hormones to maintain reproductive capacity and hor-mone homeostasis.Ovarian aging,characterized by de-clines in follicle quantity and oocyte quality,leads to premature ovarian failure,premature ovarian insufficiency,or diminished ovarian reserve,thus contributing to female infertility.