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Spatial Transcriptomic Validation of a Biomimetic Model of Fibrosis Enables Re-Evaluation of a Therapeutic Antibody Targeting LOXL2

Joseph A. Bell,Elizabeth R. Davies,Christopher J. Brereton,Milica Vukmirovic,James J. W. Roberts,Kerry Lunn,Leanne Wickens,Franco Conforti,Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer,David A. Johnston,Andres F. Vallejo,Aiman Alzetani,Sanjay Jogai,Ben G. Marshall,Aurelie Fabre,Luca Richeldi,Phillip D. Monk,Paul Skipp,Naftali Kaminski,Emily Offer,Yihua Wang,Donna E. Davies,Mark G. Jones

Cell Reports Medicine（2024）

Cited 0|Views5
Key words
fibrosis,spatial transcriptomics,disease-relevant biomimetic models,LOXL2,target engagement
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