NiH-Catalyzed Regio- and Enantioselective Hydroalkylation for the Synthesis of - or -Branched Chiral Aromatic N-Heterocycles

A nickel hydride-catalyzed regio- and enantioselective hydroalkylation reaction was developed to give access to a library of chiral beta- or gamma-branched aromatic N-heterocycles. This intriguing asymmetric transformation features excellent selectivities, step- and atom-economies, and generating two kinds of chiral products through one synthetic strategy. Furthermore, the possible reaction mechanism was extensively investigated using numerous control experiments and density functional theory calculations.