24-norursodeoxycholic acid ameliorates experimental alcoholic liver disease and activates hepatic peroxisome proliferator-activated receptor gamma

Christoph Grander, M. Meyer,Daniel Steinacher,Thierry Claudel, Manuel Grander,Bela Hausmann,Petra Pjevac,Barbara Enrich,Felix Grabherr,Georg Oberhuber, Anne Marie Z. Jukic,Julian Schwärzler,Timon E. Adolph,Günter Weiss,Michael Trauner,Herbert Tilg

Zeitschrift Fur Gastroenterologie（2023）

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摘要

Background The limited treatment options in alcoholic liver disease (ALD) remain one of the major healthcare problems worldwide. For example, alcohol associated cirrhosis-related deaths are rising globally and ALD is still the main driver of liver transplantation in Europe. In this project, we explored if the synthetic bile acid 24-norursodeoxycholic acid (norUDCA) could serve as novel therapeutic in experimental ALD.

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关键词

experimental alcoholic liver disease,proliferator-activated

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