The relationship between glutamate and resting-state connectivity in chronic cannabis users

Previous preclinical and human studies have demonstrated that cannabis (CB) use is associated with disruptions in neurochemistry, brain function, and cognition. More specifically, glutamate and resting-state connectivity have both been found to be affected by chronic and acute CB use. As the most abundant excitatory neurotransmitter, glutamate is thought to be a driver of the neuronal fluctuations that underlie connectivity. Because both glutamate and connectivity are critical to cognition and behavior, it is important to characterize the effect of CB on the relationship between them. There are few studies taking a multimodal approach to examine all three simultaneously. This chapter provides a review of the current literature and demonstrates the need for future multimodal studies with larger sample sizes.