Effect of plasma-derived exosomes from HNSCC patients on NF-κB signaling in macrophages

Introduction As one of the most immunosuppressive cancers, head and neck squamous cell carcinomas (HNSCC) show an increased NF-κB activation with downstream production of Treg attracting factors. Plasma-derived exosomes from HNSCC patients contain molecules, which can contribute to the immunosuppressive tumor microenvironment (TME). Here, we investigate the influence of plasma-derived exosomes of HNSCC patients on macrophages.