IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells

Shivam Rai,Yang Zhang,Elodie Grockowiak,Quentin Kimmerlin,Nils Hansen,Cedric B. Stoll,Marc Usart,Damien Luque Paz,Hui Hao-Shen, Yexuan Zhu, Julien Roux,Michael S. Bader,Stefan Dirnhofer, Christopher J. Farady,Timm Schroeder,Simón Méndez-Ferrer,Radek C. Skoda

Blood Advances（2024）

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摘要

•In a mouse model of oligo-clonal MPN, IL-1β favors disease initiation by promoting early expansion of a sub-clinical JAK2-V617F clone•Anti-IL-1β antibody treatment during the early expansion phase of the JAK2-mutant clone reduced the frequency of MPN disease initiation

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mpn disease initiation,cells

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