An amphiphilic material arginine–arginine–bile acid promotes α-synuclein amyloid formation

Yuxi Lin,Sohyeon Park,Eugene Bok,Yunseok Heo,Seong-Bin Yang,Yoon-Sun Yi, Jun-Hyuck Lee, Dong-Ho Seo,Eunae Jo,Sungsu Lim,Yun Kyung Kim,József Kardos,Kyoung‐Seok Ryu,Jaekwang Kim,Jooho Park, Lee YH

Nanoscale（2023）

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摘要

We developed a novel amphiphilic material, arginine-arginine (RR)-bile acid (BA). RR-BA selectively binds to aSN in Parkinson’s disease and boosts aSN amyloidogenesis through a mechanism of electrostatic binding-hydrophobic condensation.

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关键词

amyloid,amphiphilic material arginine–arginine–bile,arginine–arginine–bile acid

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