Specific NPC1 loss in microglia of the mouse brain leads to neuroinflammation and results in synaptic loss
61. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin Nuklearmedizin - NuclearMedicine(2023)
摘要
Ziel/Aim Microglial activation is one hallmark in the pathology of the lipid storage disease Niemann-Pick type C. It remains unclear if microgliosis is caused by lysosomal storage or as a reactive upregulation to neuronal cell death. Hence, we created a knock-out mouse model with a specific loss of NPC1 in microglia and characterized it by imaging biomarkers for inflammation and synaptic function.
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关键词
microglia,neuroinflammation,specific npc1 loss,mouse brain
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