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A Single Residue within the MCR-1 Protein Confers Anticipatory Resilience

Renate Frantz,Konrad Gwozdzinski,Nicolas Gisch,Swapnil Doijad,Martina Hudel,Maria Wille,Mobarak Abu Mraheil,Dominik Schwudke,Can Imirzalioglu,Linda Falgenhauer,Michael Ehrmann,Trinad Chakraborty

Microbiology spectrum（2023）

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Abstract
The global presence of transferable mcr genes in a wide range of Gram-negative bacteria from clinical, veterinary, food, and aquaculture environments is disconcerting. Its success as a transmissible resistance factor remains enigmatic, because its expression imposes fitness costs and imparts only moderate levels of colistin resistance.
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protein,resilience,single residue
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