Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics

Aaron Nolan,Merve S Zeden,Igor Kviatkovski,Christopher Campbell,Lucy Urwin,Rebecca M. Corrigan,Angelika Gründling,James P. O’Gara

MBio（2023）

Cited 10|Views8

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Abstract

The clinical burden of infections caused by antimicrobial resistant (AMR) pathogens is a leading threat to public health. Maintaining the effectiveness of existing antimicrobial drugs or finding ways to reintroduce drugs to which resistance is widespread is an important part of efforts to address the AMR crisis.

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Key words

Staphylococcus aureus,MRSA,purine metabolism,antibiotic adjuvant,β-lactam resistance,c-di-AMP

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