EVALUATION OF IMMUNE RESPONSE ABILITY OF CIMAvax-EGF® VACCINE ON ICR MOUSE

The study evaluated the immune response of CIMAvax-EGF® vaccine on Mlac: ICR mouse line has compared with the control serum samples on MNRI mouse by ELISA. The study results showed that with the designed immunogenic doses (0.1; 0.15; 0.2; 0.25 & 0.3 ml of CIMAvax-EGF® vaccine/mouse) after 14 days, using 03 serum dilutions include: 1/100, 1/1000 & 1/10000 for ELISA test gave similar results to the NMRI mouse serum standard sample provided by the manufacturer. The optimal immunogenic dose in Mlac: ICR mouse line is 0.2ml of CIMAvax-EGF® vaccine/mouse. From the above research results, it was possible to use Mlac: ICR mouse line of National Institute for Control of Vaccines and Biologicals (NICVB) at NICVB's laboratory for potency test of CIMAvax-EGF® vaccine produced by Cuban.